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What is Gut Microbiome Transplantation (GMT)?

Gut microbiome transplantation (GMT) is also known as faecal microbiota transplantation (FMT). GMT is the transfer of healthy bacteria-rich stool from a healthy person into the gastrointestinal tract of a sick person in order to restore bacterial balance. GMT is a widely accepted treatment for recurrent infections, with cure rates of up to 90%.¹ This treatment has been carried out at Singapore’s National University Hospital since 2014 and about 48,000 GMTs are performed yearly in the United States alone.^2,3

Transfer of healthy bacteria-rich stool into the gastrointestinal tract of a sick person during FMT to restore bacterial balance.

How is GMT administered?

GMT can be administered directly to the colon via colonoscopy or through the upper gastrointestinal tract via capsule ingestion.

Colonoscopy

Oral Capsule

References

¹Baunwall S, Lee MM, Eriksen MK, et al. Faecal microbiota transplantation for recurrent Clostridioides difficile infection: An updated systematic review and meta-analysis. EClinicalMedicine. 2020;29-30.https://doi.org/10.1016/j.eclinm.2020.100642. Accessed 23 May 2022.
²Doctors perform Singapore’s first faecal transplants.TODAYonline website. https://www.todayonline.com/singapore/doctors-perform-singapores-first-fecal-transplants.
³Mamoon L, Olesen SW. Fecal Microbiota Transplants Annually and Their Positive Clinical Impact. Clinical and Translational Gastroenterology. 2022;11(11):e00247.